Abstract #0738

Impact of Cocaine Use on Brain Metabolism: Hypoactivity, Dose Dependence, and Relationship to Cognitive Ability

Peiying Liu¹, Bryon Adinoff²,³, Carol Tamminga², Francesca Filbey⁴, Hanzhang Lu¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States; ²Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States; ³VA North Texas Health Care System, Dallas, TX, United States; ⁴Center For Brain Health, University of Texas at Dallas, Dallas, TX, United States

Long-term cocaine use is known to negatively impact neural systems. Cerebral metabolic rate of oxygen (CMRO2) is thought to be a direct index of neural activity, but no measurements of brain oxygen metabolism in cocaine-addicted patients has been reported. We used a non-invasive, fast and reliable MR method to examine impact of long-term cocaine use on CMRO2. We sought to answer three questions: 1) is CMRO2 in cocaine-addicted participants significantly different from that in healthy controls? 2) is there a relationship between cocaine use and the severity of metabolic deficit? 3) does the degree of CMRO2 deficit predict cognitive ability?