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Abstract #0784

Clinical Utility of NODDI in Assessing Patients with Epilepsy Due to Focal Cortical Dysplasia

Gavin P. Winston1, Mark R. Symms1, Daniel C. Alexander2, John S. Duncan1, Hui Zhang2

1Epilepsy Society MRI Unit & Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom; 2Department of Computer Science & Centre for Medical Image Computing, University College London, London, United Kingdom

NODDI (neural orientation dispersion and density imaging) is a multi-compartment diffusion model that can distinguish two key variables contributing to FA changes - neurite density and orientation dispersion - with a clinically feasible scan protocol (20 minutes).