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Abstract #0796

Brain Microstructure Assessed by CHARMED and NODDI in the Newborn

Nicolas Kunz1, Hui Zhang2, Yaniv Assaf3, Franois Lazeyras4, Daniel Alexander2, Petra Susan Hppi1, 5

1Pediatrics, University of Geneva, Geneva, Switzerland; 2Computer Science, University College London, London, United Kingdom; 3Neurobiology, Tel Aviv University, Tel Aviv, Israel; 4Radiology-CIBM, Geneva University Hospitals, Geneva, Switzerland; 5Department of Neurology, Childrens Hospital, Geneva, Switzerland

Diffusion tensor imaging (DTI), may be the only feasible technique to study micorstructural changes occurring during the brain development. The main aims of this study was to design a complete new pipeline to perform micro-structural diffusion analysis in neonatal brain and to compare DTI to CHARMED and NODDI, which provides new microstructural metrics such as the intra-axonal volume fraction (VFia). High quality subject template was generated using DTI-TK tensor registration tools, which allows the accurate definitions of 13 ROIs. FA and VFia were able to depict fine mircostructural differences in early maturation fiber tracts.