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Abstract #0822

Long-Time-Scale Hyperpolarized 3He Diffusion MRI Is More Sensitive Than Short-Time-Scale 3He Diffusion MRI for Detecting COPD

Chengbo Wang1, 2, John P. Mugler, III2, 3, Eduard E. De Lange2, G Wilson Miller2, Talissa A. Altes2

1Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo, Zhejiang, China; 2Radiology and Medical Imaging, University of Virginia, CHARLOTTESVLE, VA, United States; 3Biomedical Engineering, University of Virginia, CHARLOTTESVLE, VA, United States

Co-registered axial helium-3 apparent diffusion coefficient (ADC) maps were obtained in 24 healthy subjects and 15 patients with COPD using both short-time scale (STS) and long-time scale (LTS) techniques. Global histograms of all pixel-wise ADC values from all subjects showed a better separation of the COPD subjects from the healthy subjects for the LTS technique compared to the STS technique. A ROC analysis indicated that the LTS ADC method has a greater area under the ROC curve (LTS: 0.920 vs. STS: 0.849), suggesting that the LTS ADC is more sensitive to COPD than the STS ADC.