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Abstract #0852

Cerebrovascular Reactivity Measured Using Targeted Hypo/Hypercapnia BOLD Imaging at 7T

Alex Bhogal1, Marielle E.P. Philippens2, Joe Fisher3, Jeroen Cornelis Willem Siero1, 4, Peter R. Luijten2, Hans Hoogduin1

1Radiology, UMC Utrecht, Utrecht, Netherlands; 2Radiotherapy, UMC Utrecht, Utrecht, Netherlands; 3Thornhill Research Inc., Toronto, Ontario, Canada; 4Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, Netherlands

Cerebrovascular Reactivity (CVR) is measured using targeted PaCO2 breathing challenges in combination with BOLD-EPI imaging at 7T. While maintaining normoxia, traditional block stimulus response is compared with a uniformly increasing PaCO2 'ramp'stimulus. Ramp results are modeled using sigmoidal and linear functions to obtain more information with respect to CVR dynamics and increase calibration accuracy for signal changes attributable to vessel reactivity.