Abstract #0854

Quantitative Standardization of Volumetric Whole-Brain MR Spectroscopic Imaging

Mohammad Sabati¹, Sulaiman Sheriff¹, Meng Gu², Henry Zhu³, Peter B. Barker³, Daniel Spielman², Andrew A. Maudsley¹

¹Radiology, University of Miami, Miami, FL, United States; ²Radiology, Stanford University, Stanford, CA, United States; ³Radiology, Johns Hopkins University, Baltimore, MD, United States

MR spectroscopic imaging (MRSI) offers considerable potential for detection of alterations in tissue metabolism; however, the use of current techniques for clinical studies and multi-center trials remains limited due to variability of implementations across sites and manufactures scanners; restrictive implementations in terms of the spatial extent over which data is obtained; and relative complexity of the data analysis. To address these limitations a standardized volumetric whole-brain 1H MRSI sequence has been implemented on scanners from three different manufacturers at three sites and combined with a fully automated MRSI processing procedure. Results were compared using a spectroscopic phantom and thirty aged-matched normal subjects.