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Abstract #0854

Quantitative Standardization of Volumetric Whole-Brain MR Spectroscopic Imaging

Mohammad Sabati1, Sulaiman Sheriff1, Meng Gu2, Henry Zhu3, Peter B. Barker3, Daniel Spielman2, Andrew A. Maudsley1

1Radiology, University of Miami, Miami, FL, United States; 2Radiology, Stanford University, Stanford, CA, United States; 3Radiology, Johns Hopkins University, Baltimore, MD, United States

MR spectroscopic imaging (MRSI) offers considerable potential for detection of alterations in tissue metabolism; however, the use of current techniques for clinical studies and multi-center trials remains limited due to variability of implementations across sites and manufactures scanners; restrictive implementations in terms of the spatial extent over which data is obtained; and relative complexity of the data analysis. To address these limitations a standardized volumetric whole-brain 1H MRSI sequence has been implemented on scanners from three different manufacturers at three sites and combined with a fully automated MRSI processing procedure. Results were compared using a spectroscopic phantom and thirty aged-matched normal subjects.