Abstract #0896

Regional Changes of Cortical Thickness and Cortical Surface in Children Born Prematurely and Children Born with Intrauterine Growth Restriction at School Age

Lana Vasung¹, Laura Gui¹, Elda Fischi-Gomez¹,², Cristina Borradori-Tolsa³, Franois Lazeyras⁴,⁵, Petra Susan Hppi¹

¹Division of Development and Growth, Department of Pediatrics, University of Geneva, Geneva, Switzerland; ²Signal Processing Laboratory 5(LTS5), cole Polytechnique Fdrale de Lausanne (EPFL), Lausanne, Switzerland; ³Division of Development and Growth, Department of Pediatrics, University of Geneva and University Hospital Geneva, Geneva, Switzerland; ⁴Department of Radiology, University of Geneva and University Hospital Geneva, Geneva, Switzerland; ⁵Center for Biomedical Imaging (CIBM), Geneva and Lausanne, Switzerland

The growing incidence of prematurely born children with or without intrauterine growth restriction and the improvement of survival rates has been associated with highly problematic long term neurodevelopmental outcomes. Brain structural alterations, associated with these mainly cognitive difficulties, most likely involve cortical organization. This study presents new ways of assessing structural organization of the cortex through thickness and surface measurements in children born prematurely with or without intrauterine growth restriction at the school age.