Abstract #0901

Comparing Diffusion Tensor Imaging Metrics of Motor and Sensory Tracts in Children with Spastic Cerebral Palsy and the Levels of Gross Motor Function by TBSS and Tractography

Jiang Hao Xiang¹,², Li Xian jun³,⁴, Gao Jie³, Song Yang⁵, Zhang Zhe³, Zhang Zeng jun⁶, Yang Jian⁷

¹Department of Radiology, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xi'an, Shan xi, China; ²Department of Radiology, The Xian children's hospital, Xian , Shan xi , China; ³Department of Radiology, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian, Shan xi, China; ⁴Department of Biomedical Engineering, School of Life Science and Technology, Xi' an Jiaotong University, Xi' an , Shan xi, China; ⁵Child healthcare Department, The First Affiliated Hospital of Medical College, Xian Jiaotong University, Xian, Shan xi, China; ⁶Department of Radiology, The Xian children's hospital, Xian, Shan xi, China; ⁷Department of radiology, The First Affiliated Hospital of Medical College, Xian Jiaotong University.Xian, Xian, Shan xi, China

The aim of this study is to employ DTI with tract-based spatial statistics (TBSS) and quantitative tractography to further evaluate the correlation between DTI metrics of motor and sensory tracts with gross motor function. 23 children with bilateral spastic cerebral palsy (CP) underwent T1WI, T2WI, and DTI were collected. We demonstrated that FA values in the most of white matter tracts show a significant negative correlation with levels of Gross Motor Function Classification System (GMFCS), and the FA values and fiber count of corticospinal tract (CST) were strongly negative correlated with GMFCS levels. In addition, there were low negative correlations between DTI metrics of superior thalamic radiation (STR) and GMFCS levels, and between the FA values of posterior thalamic radiation (PTR) and the GMFCS levels. The results demonstrated that the CST played a major role in the development of clinical motor and sensory function.