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Abstract #0907

White Matter Variations in Children with Spastic Cerebral Palsy Analyzed by Diffusion Tensor Imaging with Tract-Based Spatial Statistics and Probabilistic Tractography

Jiang Hao Xiang1, Yang Jian2

1Department of radiology, Xi'an Jiaotong University, Xi'an, Shan xi, China; 2Department of radiology, Xian Jiaotong University., Xian, Shan xi, China

The aim of this study is to employ DTI with tract-based spatial statistics (TBSS) and probabilistic tractography to investigate the WM microstructural changes in children with spastic cerebral palsy (CP). 23 children with bilateral spastic CP and 23 healthy children with matched age and sex were collected. We demonstrated that decreased FA but increased MD, RD within extensive WM tracts in children with CP. Meanwhile, the volume and fibers loss of PTR and SCC was lower significantly in CP group. We inferred that in children with spastic CP, the PTR and SCC were more vulnerable since the injury of sensorimotor loops involving in CST.