Abstract #0913

Abnormal Functional Network Connectivity Among Spatially Independent Resting State Networks in Children with Frontal Lobe Epilepsy

Mojdeh Zamyadi¹, Charles Raybaud¹, Carter Snead², Mary Lou Smith³, Elysa Widjaja¹

¹Diagnostic Imaging, The Hospital for Sick Children, Toronto, Ontario, Canada; ²Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada; ³Department of Psychology, The Hospital for Sick Children, Toronto, Ontario, Canada

In this study functional connectivity (FC) within resting states networks (RSNs) was assessed using independent component analysis (ICA) in healthy controls and children with frontal lobe epilepsy (FLE). In addition, functional network connectivity (FNC) was evaluated across several RSNs by examining the time series of the components. Based on the statistical analysis of FC results, we identified 6 RSNs in both groups. We have also demonstrated both reduced and elevated FC within the RSNs and in FNC across the RSNs. The findings of this study provide evidence on the effect of localization-related epilepsy, in this case FLE, on several RSNs.