Ross W. Mair1,
2, Martin Reuter2, 3, Andr J. W. van der Kouwe2,
Bruce Fischl2, 4, Randy Buckner1, 2
1Center
for Brain Science, Harvard University, Cambridge, MA, United States; 2Martinos
Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown,
MA, United States; 3Dept. of Mechanical Engineering, Massachusetts
Institute of Technology, Cambridge, MA, United States; 4Computer
Science and Artificial Intelligence Laboratory, Massachusetts Institute of
Technology, Cambridge, MA, United States
The multi-echo MPRAGE (MEMPRAGE) sequence was implemented to reduce signal distortion by acquiring at a higher bandwidth and averaging multiple echoes to recover SNR while providing additional T2* information that can enhance cortical segmentation. Here, we validate the morphometric results obtained from a rapid 2-minute MEMPRAGE scan with four-fold acceleration by comparison to those from a 6-minute, 1 mm isotropic, two-fold accelerated MEMPRAGE scan acquired in the same session. The results indicate that the rapid 2-minute MEMPRAGE protocol can be used in place of the longer, higher-resolution MEMPRAGE scan without degradation of the quantitative morphometric results obtained.