Osamu Togao1, 2, Takashi Yoshiura2, Jochen Keupp3, Akio Hiwatashi2, Koji Yamashita2, Kazufumi Kikuchi2, Yuriko Suzuki4, Mariya Doneva3, Koji Sagiyama5, Masaya Takahashi5, Hiroshi Honda2
1Molecular Imaging and Diagnosis, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan; 2Clinical Radiology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan; 3Philips Research Europe, Hamburg, Germany; 4Philips Electronics Japan, Minato-ku, Tokyo, Japan; 5Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States
Amide proton transfer (APT) imaging employs the exchange between protons of free tissue water and the amide groups (-NH) of endogenous mobile proteins and peptides, imaged by a chemical exchange saturation transfer technique. APT imaging is expected to be a non-invasive method to measure proteins and peptides level in active tumors. In this study, we demonstrated the ability of APT imaging for prediction of histopathological grades of diffuse gliomas in a large patient population with histopathological evaluations.