Abstract #0977

Reduced Diffusion and Perfusion in Bevacizumab-Induced Diffusion Restricted Necrosis Versus Brain Tumor Hypercellularity

Peter S. LaViolette¹, Elizabeth Cochran², Alexander D. Cohen³, Mona Al-Gizawiy¹, Jennifer Connelley⁴, Scott D. Rand¹, Mark G. Malkin⁴, Kathleen M. Schmainda¹

¹Radiology, Medical College of Wisconsin, Milwaukee, WI, United States; ²Pathology, Medical College of Wisconsin, Milwaukee, WI, United States; ³Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; ⁴Neurology, Medical College of Wisconsin, Milwaukee, WI, United States

Recent conflicting reports show that regions of bevacizumab induced restricted diffusion, as measured with DWI MRI contain neoplastic hypercellularity or atypical necrosis. In this study we look at one sample from a glioblastoma patient ex-vivo. We find that regions of dark ADC contain both hypercellularity and necrosis. Regions of necrosis had more restricted diffusion than regions of hypercallularity. rCBV was also decreased in necrotic regions compared to hypercellularity.