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Abstract #0990

Blood-Brain Barrier Pathology in Dementia: Dual Time Resolution Dynamic Contrast Enhanced-MRI Assessment

Harm J. van de Haar1, Saartje Burgmans1, Thijs van Osch2, Jacobus Jansen3, Frank C.G. van Bussel1, Cecile RLPN Jeukens3, Mark A. van Buchem2, Paul A.M. Hofman3, Frans RJ Verhey1, Walter H. Backes3

1Maastricht University, Maastricht, Limburg, Netherlands; 2Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands; 3Maastricht University Medical Center, Maastricht, Limburg, Netherlands

A potential underlying mechanism for dementia through Alzheimers Disease (AD) could be that microscopic vascular abnormalities cause leakage of the blood brain barrier prior to neuronal damage. The primary aim of this pilot study is to assess the feasibility of detecting this damage in terms of the pharmacokinetic parameters fractional blood volume (vb) and leakage (Ki), in brains suffering from (preclinical) AD with a dual-temporal resolution DCE-MRI sequence. Also, the minimally required scan duration was investigated.