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Abstract #0995

Age-Dependent Changes in White-Matter and Gray Matter Brain T1rho Values

Richard Watts1, Trevor Andrews1, 2, Scott Hipko1, Jay Gonyea1, Christopher G. Filippi1, 3

1Department of Radiology, University of Vermont College of Medicine, Burlington, VT, United States; 2Philips Healthcare, Cleveland, OH, United States; 3Department of Radiology, Columbia University Medical Center, New York, NY, United States

T1&[rho] is sensitive to the macromolecular content of biological tissue. Quantitative whole-brain T1&[rho] maps were obtained from 41 control subjects aged 18-76 using a fluid attenuated 3D turbo spin echo technique. T1&[rho] from cortical grey matter showed a negative correlation with age (r=-0.599, p<0.001) major white matter tracts showed a positive correlation (r=0.527, p<0.001), and juxtacortical white matter showed no significant correlation (r=0.035, p=0.830). This study presents the first systematic study of T1&[rho] in normal aging, and provides normative data for future studies of disease pathology.