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Abstract #0999

R2* in the Normal Ageing Brain and Its Relation to Serum Iron

Lukas Pirpamer1, Christian Langkammer1, Stephan Seiler1, Christian Enzinger1, Franz Fazekas1, Reinhold Schmidt1, Stefan Ropele1

1Department of Neurology, Medical University of Graz, Graz, Styria, Austria

R2* has been recently validated as a measure for brain iron. This study investigated the relationship between serum levels of iron and R2* in white matter hyperintensities (WMH) and deep gray matter structures. R2* mapping was done in 275 normal ageing subjects. R2* in deep gray matter was not related to serum level of iron or WMH severity. However, subjects suffering from hypertension and a high WMH score showed a significant correlation between lesional R2* and iron concentration in the serum thus underlining the role of microangiopathy in the development of WMH.