Abstract #1005

Alzheimer's Disease Risk Variant Within the CLU Gene Affects White Matter Microstructure and Function in Nondemented Subjects

Lihua Qiu¹,², Yong He³, Yi Zhou³, Hehan Tang¹, Qiuju Huang¹, Ling Zou¹, Lanlan Wang³, Qiyong Gong¹

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China; ²Radiology, The second people's hospital of Yibin, Yibin, Sichuan, China; ³Department of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China

Alzheimers disease (AD) is the most common form of dementia and is highly heritable. In the present study, we investigate the FA change in nondemented subjects with AD risk gene of C allele in clusterin (CLU). We found nondemented healthy carriers of the CLU gene risk variant showed both increased and decreased FA in risk CC genotype group which may relate with some abnormal function and increase vulnerability to developing AD later in life.