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Abstract #1010

Altered Causal Connectivity of Resting State Brain Networks in Amnesic MCI

Peipeng Liang1, Zhihao Li2, Gopikrishna Deshpande3, Zhiqun Wang1, Xiaoping P. Hu2, Kuncheng Li1

1Dept. of Radiology, Xuan wu Hospital, Capital Medical University, Beijing, China; 2Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States; 3Department of Electrical and Computer Engineering, and Department of Psychology, Auburn University, Auburn, AL, United States

The present study applied correlation-purged Granger causality analysis (CPGC) to investigate the effective connectivity of four basic networks in 16 aMCI patients and 16 matched healthy controls C default mode network (DMN), hippocampal cortical memory network (HCMN), dorsal attention network (DAN) and fronto-parietal control network (FPCN). It was found that, as contrast to healthy controls, aMCI exhibited significantly reduced within-FPCN (anterior-posterior) and hippocampus centered causal connectivity, together with enhanced within-DMN and within right frontal cortex causal connectivity. The current study demonstrated the coexistence of causal disconnection and compensation in aMCI patients, and might provide insights into biological mechanism of the disease.