Meeting Banner
Abstract #1012

MRI of the Neurological Effects in a Rat Model of Hypertension

Adam Bernstein1, Sumana Veeravelli1, Alexander Alvarez1, Megan Fitzhugh1, Eriko Yoshimaru1, Michael Valdez1, John Totenhagen1, Kewei Chen2, James Moeller3, Paul Coleman4, Kenneth Mitchell5, Matt Huentelman6, Carol Barnes1, Gene Alexander1, Theodore Trouard1

1University of Arizona, Tucson, AZ, United States; 2Banner Alzheimer's Institute, Phoenix, AZ, United States; 3Columbia University, New York, NY, United States; 4Banner Sun Health Research Institute, Sun City, AZ, United States; 5Tulane University, New Orleans, LA, United States; 6Translational Genomics Research Institute, Phoenix, AZ, United States

Susceptibility weighted imaging (SWI), diffusion tensor imaging (DTI), high-resolution anatomical imaging and cognitive performance tests were carried out on a transgenic rat model of hypertension (HTN). After 6 weeks of HTN, significant differences between hypertensive and normotensive animals were seen in learning and memory function as well as in fractional anisotropy and patterns of gray matter volume.