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Abstract #1017

in vivo Quantification of Excitatory and Inhibitory Neurotransmitters in Amyotrophic Lateral Sclerosis

Sanjay Kalra1, Peter Seres1, Changho Choi2

1University of Alberta, Edmonton, Alberta, Canada; 2University of Texas Southwestern Medical Center, Dallas, TX, United States

Single voxel spectroscopy of glutamate and GABA was performed at 3T in the motor cortex in patients with ALS. Glutamate was decreased 13%. GABA was unchanged, however correlations with clinical indices were present for both glutamate and GABA.