Xiaojun Xu1, Qidong Wang2, Minming Zhang1
1No.2 Hospital Zhejiang University School of Medicine, Hangzhou , Zhejiang, China; 2No.1 Hospital Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
We found that increased iron deposition would cause a decrease in the estimated diffusivity and an increase in the estimated anisotropy. This finding indicates that iron deposition influences significantly the measurement of water diffusion tensor in the human brain. Caution is needed in use of DTI metrics for diagnosis of various neurological diseases involving abnormal iron or other paramagnetic substances deposition, particularly at higher fields.