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Abstract #1035

Laminar Specific Detection of Amyloid Precursor Protein -Induced Neurodegeneration and Recovery Using MEMRI in an Olfactory Based Alzheimers Disease Mouse Model.

Galit Saar1, Ning Cheng2, Leonardo Belluscio2, Alan P. Koretsky1

1LFMI/NINDS, NIH, Bethesda, MD, United States; 2DNPU/NINDS, NIH, Bethesda, MD, United States

MEMRI was used to detect specific laminar changes in olfactory bulb (OB) to follow the progression of APP-induced neuronal pathology and its recovery in a reversible olfactory-based AD mouse model. OB volume and manganese enhancement of the glumerular layer in OB were decreased dramatically in mutant mice. Turning off APP overexpression with doxycycline, resulted in an increase in manganese enhancement of the glomerular layer after only 1 week, with farther recovery after 3 weeks. Moreover, APP antibody treatment showed an increase enhancement in the treated OB and demonstrate the potential of MRI in this mouse model to assess neuroprotective strategies.