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Abstract #1040

Dynamic MRI in the Rat Brain at 3.0 T for Measuring Permeability of the Blood-Brain Barrier in Glioblastoma Multiforme

Hunter R. Underhill1, Robert C. Rostomily1

1Neurological Surgery, University of Washington, Seattle, WA, United States

We present a method for quantitatively measuring the voxel-based blood-brain barrier permeability associated with glioblastoma multiforme in the in vivo rat brain at 3.0 T using a continuous infusion of gadolinium. The technique is based on a simplification of the Brix method and yields ktrans-maps after accounting for pixel-based variations in R1 and B1.