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Abstract #1045

MRI Correlates of Dendrite Abnormalities in the MeCP2-A140V Mouse Model of Rett Syndrome

Gregory H. Turner1, Qingwei Liu1, Shannon L. Olfers2, Garilyn M. Jentarra3, Sampathkumar Rangasamy2, Vinodh Narayanan2

1Neuroimaging Research, Barrow Neurological Institute, Phoenix, AZ, United States; 2Developmental Neurogenetics Research, Barrow Neurological Institute, Phoenix, AZ, United States; 3Biochemistry, Midwestern University, Glendale, AZ, United States


Mutations of the gene MeCP2 have been shown to cause Rett syndrome and are associated with other neurodevelopmental disorders such as autism and X-linked mental retardation. These mutations result in altered dendrite pathology and abnormal fine dendrite structure. DTI was used to measure alterations in FA in cortical gray matter in WT and MeCP2-A140V mutant mice and to evaluate its potential as a non-invasive biomarker of dendritic branching complexity.