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Abstract #1063

Diffusion MRI Study of Slowly Growing Human Glioma Models in Mice at 14.1T

Paola Porcari1, 2, Monika E. Hegi3, Virginie Clment-Schatlo4, Marie-France Hamou3, Irene Vassallo3, Denis Marino4, Silvia Capuani5, 6, Rolf Gruetter7, 8, Vladimr Mlynrik1

1Center for Biomedical Imaging, EPFL, Lausanne, Switzerland; 2Physics Department, Sapienza University of Rome, Rome, Italy; 3Department of Clinical Neuroscience, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland; 4Department of Clinical Neuroscience, University Hospital of Geneva, Geneva, Switzerland; 5Physics Department, Sapienza University, Rome, Italy; 6CNR-IPCF UOS Roma Sapienza, Physics Department, Sapienza University of Rome, Rome, Italy; 7Center for Biomedical Imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 8Departments of Radiology, Universities of Lausanne and Geneva, Lausanne and Geneva, Switzerland

Diffuse tumors growing from glioma cell xenografts in brain of immunodeficient mice are difficult to study by standard MRI techniques. We aimed to investigate feasibility of diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) for early detection of these tumors. We also compared diffusion properties of tumors grown in two different glioma models. In contrast to T2-weighted images, the tumors were visible in diffusion-weighted images and diffusion maps. Two studied tumor models showed different diffusion parameters in DWI and DTI.