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Abstract #1065

Changes in Connectivity Associated with Neuronal Migration Disorder as Assessed by Diffusion Tractography

Emi Takahashi1, Glenn D. Rosen2, Allison C.R. Scott3, Veronica J. Peschansky2, Natsuko Fujisaki2, Guangping Dai4, Patricia Ellen Grant5, Albert M. Galaburda2

1Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; 2Beth Israel Deaconess Medical Center, Boston, MA, United States; 3Columbia University, New York, NY, United States; 4Massachusetts General Hospital, Boston, MA, United States; 5Boston Children's Hospital, Boston, MA, United States

The goal of this study is to use non-invasive diffusion weighted imaging and tractography to develop a quantifiable and verifiable biomarker of neuronal migration disorder. Our results suggest that the number and volume of identified tractography pathways were significant predictors of neuronal migration disorders in callosum and intra-hemispheric pathways. The length of tractogrpahy pathways was also a significant predictor of the disorders in the total and intra-hemispheric pathways. These experiments clearly support the notion that there are profound changes in the nature of connectivity associated with disruption of neuronal migration.