Abstract #1065

Changes in Connectivity Associated with Neuronal Migration Disorder as Assessed by Diffusion Tractography

Emi Takahashi¹, Glenn D. Rosen², Allison C.R. Scott³, Veronica J. Peschansky², Natsuko Fujisaki², Guangping Dai⁴, Patricia Ellen Grant⁵, Albert M. Galaburda²

¹Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; ²Beth Israel Deaconess Medical Center, Boston, MA, United States; ³Columbia University, New York, NY, United States; ⁴Massachusetts General Hospital, Boston, MA, United States; ⁵Boston Children's Hospital, Boston, MA, United States

The goal of this study is to use non-invasive diffusion weighted imaging and tractography to develop a quantifiable and verifiable biomarker of neuronal migration disorder. Our results suggest that the number and volume of identified tractography pathways were significant predictors of neuronal migration disorders in callosum and intra-hemispheric pathways. The length of tractogrpahy pathways was also a significant predictor of the disorders in the total and intra-hemispheric pathways. These experiments clearly support the notion that there are profound changes in the nature of connectivity associated with disruption of neuronal migration.