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Abstract #1068

Longitudinal Blast Injury Chracterization Using Magnetic Resonance Spectroscopy in Rat Hippocampus

Sankar Seramani1, Sanjay K. Verma1, Kian Chye Ng2, Enci Mary Kan2, Bhanu Prakash K.N. 1, Tan Mui Hong2, Jia Lu2, Sendhil S. Velan1, 3

1Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, Singapore, Singapore; 2Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore; 3Clinical Imaging Research Centre, Agency for Science, Technology and Research, Singapore, Singapore

Mechanisms underlying secondary cell death due to Traumatic brain injury (TBI) are poorly understood. Recent advances in magnetic resonance spectroscopy (MRS) allow us to observe highly resolved metabolic changes in the brain after the injury. MRS offers a unique window to identify the severity of the injury, outcome of the injury and secondary insult. Here in this work animal injury of the blast model is conducted and we are also seeing a similar trend which shows significant reduction in NAA/(total Choline ) concentration. Our histochemistry results are also confirming the damage of neural nucleus at 72 hrs after the injury.