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Abstract #1074

Progression of Brain Volume Reduction in a Rat Model of STZ-Induced Type 1 Diabetes Studied by Anatomical Imaging Combined with Voxel-Based Morphometry

Wei Huang1, Ziyu Cao1, Liqing Yang1, Shuxia Wang1, Lifeng Gao1, Hao Lei1

1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China

Type 1 diabetes is a chronic disease characterized as insulin deficiency and the resultant metabolic disturbances.It often accompanied with many complications, including diabetic encephalopathy.In this study, we measured volumetric changes in the brain of STZ-induced diabetic rats at 12 and 20 weeks using VBM. Progressive atrophy of STZ-induced diabetic brain was assessed.