Abstract #1074

Progression of Brain Volume Reduction in a Rat Model of STZ-Induced Type 1 Diabetes Studied by Anatomical Imaging Combined with Voxel-Based Morphometry

Wei Huang¹, Ziyu Cao¹, Liqing Yang¹, Shuxia Wang¹, Lifeng Gao¹, Hao Lei¹

¹State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, Hubei, China

Type 1 diabetes is a chronic disease characterized as insulin deficiency and the resultant metabolic disturbances.It often accompanied with many complications, including diabetic encephalopathy.In this study, we measured volumetric changes in the brain of STZ-induced diabetic rats at 12 and 20 weeks using VBM. Progressive atrophy of STZ-induced diabetic brain was assessed.