Cornelia Laule1, Vlady Pavlova1, Esther Leung1, Guojun Zhao2, Piotr Kozlowski2, Anthony L. Traboulsee3, David K.B. Li2, 3, Wayne Moore1, 3
1Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada; 2Radiology, University of British Columbia, Vancouver, BC, Canada; 3Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada
T-cells, B-cells and activated microglia in MS post-mortem brain tissue were examined. In general, similar levels of microglial activation, B-cells and T-cells were observed in diffusely abnormal white matter (DAWM) and normal appearing white matter (NAWM). While previous studies have reported myelin and axonal abnormalities in DAWM relative to NAWM, these abnormalities appear not to correlate with the degree of microglia activation or the presence of B or T-cells.