Wenshu Qian1, Koon-Ho Chan2, Queenie Chan3, Henry Ka Fung Mak1
1Diagnostic Radiology, The University of Hong Kong, Hong Kong, China; 2Medicine, The University of Hong Kong, Hong Kong, China; 3Philips Healthcare, Hong Kong, China
Pathological and MRI studies of multiple sclerosis (MS) have shown that lesions are often located in both white matter (WM) and gray matter (GM), though the ones in GM are often underestimated. Diffusion kurtosis imaging (DKI) has been applied to probe the non-Gaussian diffusion property of brain tissues in vivo and proved to be less sensitive to the partial volume effects from the CSF. In this study, we demonstrate microstructural changes in normal-appearing WM and GM in MS using DKI-derived metrics, which might serve as imaging markers for early diagnosis and prognostication of the disease.