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Abstract #1113

Extended Metabolite Profile of the Human Spinal Cord

Andreas Hock1, Bertram J. Wilm2, Erin L. MacMillan3, Roland Kreis3, Spyros S. Kollias4, Peter Boesiger2, Anke Henning2, 5

1Institute for Biomedical Engineering , University and ETH Zurich , Zurich, Switzerland; 2Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland; 3Dept. of Clinical Research and Institute of Diagnostic, Interventional and Pediatric Radiology, University of Bern, Bern, Switzerland; 4Institute of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland; 5Max Planck Institute for Biological Cybernetics, Tbingen, Germany

Clinical magnetic resonance spectroscopy is rarely applied in the spinal cord due to technical challenges leading to a low spectral quality and thus to a limited number of reliable detectable metabolites. In order to extend the metabolite profile an increase of the spectral quality is necessary, which could be achieved by both: averaging a high number of FIDs and by using a dedicated neck coil. Besides N-acetyl aspartate, creatine, choline and myo-inositol a reliable detection of scyllo-inositol and glutamine/glutamate was possible. Increased myo-inositol/creatine and scyllo-inositol/creatine ratios compared to brain estimates can be observed in the spinal cord.