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Abstract #1153

Primary Olfactory Cortex Involvement in Alzheimers Disease: A Functional and Morphological MRI Investigation

Megha Vasavada1, Jian-Li Wang1, Xiaoyu Sun1, Sarah Ryan1, Christopher Weitekamp1, Prasanna Karunanayaka1, Qing Yang1

1Penn State University, Hershey, PA, United States

Olfactory deficits are known to occur in patients with Mild Cognitive Impairment (MCI) and early AD. In this work, we performed concurrent measurements of the volumes and olfactory activations of the primary olfactory cortex (POC) and hippocampus, and demonstrated that the POC is clearly involved in early AD functionally and pathologically.