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Abstract #1158

The Altered Value-Based Intrinsic Network and Its Association with Impulsive Behavior in Abstinent Heroin Dependent Subjects

Tianye Zhai1, 2, Tianye Zhai3, Chunming Xie1, 2, Zheng Yang1, Shi-Jiang Li2

1Center of Brain and Cognition, Beijing Institute of Basic Medical Science, Beijing, China; 2Biophysics, Medical College of Wisconsin, Milwaukee, WI, United States; 3Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

Neurobiological and neuroimaging studies have demonstrated that the ventral medial prefrontal cortex (vmPFC), a major node for decision making, is crucial in drug addiction. 1,2 However, little is known about the role of the vmPFC network and its relation to drug-seeking behaviors, such as impulsivity in addiction. In this study, we utilized resting-state functional connectivity fMRI (R-fMRI) to investigate the alteration of the vmPFC network and its relationship to impulsivity in abstinent heroin dependent subjects (HD) and control nondrug users (CN).