Abstract #1160

Brain on Fire: Temporal Standard Deviation of Resting State BOLD Signal Increases in Major Depressive Disorders

Masaya Misaki¹, Vadim Zotev¹, Raquel Phillips¹, Kymberly D. Young¹, Han Yuan¹, Jonathan Savitz¹,², Wayne C. Drevets¹, Jerzy Bodurka¹,³

¹Laureate Institute for Brain Research, Tulsa, OK, United States; ²Tulsa School of Community Medicine, University of Tulsa, Tulsa, OK, United States; ³College of Engineering, University of Oklahoma, Tulsa, OK, United States

To study abnormalities from major depressive disorder (MDD) in resting-state brain activity, we compared the temporal standard deviation (tSD) of resting-state BOLD time course signals. The tSD reflects both frequency and amplitude of an individual brain region’s activity. Comparing tSDs of MDD and HC subjects revealed higher temporal variability of resting-state BOLD signal in MDD versus HC in multiple brain regions including cerebellum, cingulate cortex, thalamus, and insula, while no brain regions showed lower tSD in MDD versus HC. The result suggests that in MDD subjects these brain regions had more frequent and larger activity change in resting-state.