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Abstract #1160

Brain on Fire: Temporal Standard Deviation of Resting State BOLD Signal Increases in Major Depressive Disorders

Masaya Misaki1, Vadim Zotev1, Raquel Phillips1, Kymberly D. Young1, Han Yuan1, Jonathan Savitz1, 2, Wayne C. Drevets1, Jerzy Bodurka1, 3

1Laureate Institute for Brain Research, Tulsa, OK, United States; 2Tulsa School of Community Medicine, University of Tulsa, Tulsa, OK, United States; 3College of Engineering, University of Oklahoma, Tulsa, OK, United States

To study abnormalities from major depressive disorder (MDD) in resting-state brain activity, we compared the temporal standard deviation (tSD) of resting-state BOLD time course signals. The tSD reflects both frequency and amplitude of an individual brain region’s activity. Comparing tSDs of MDD and HC subjects revealed higher temporal variability of resting-state BOLD signal in MDD versus HC in multiple brain regions including cerebellum, cingulate cortex, thalamus, and insula, while no brain regions showed lower tSD in MDD versus HC. The result suggests that in MDD subjects these brain regions had more frequent and larger activity change in resting-state.