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Abstract #1189

Evidence of Pronounced Surface Deformation of the Subcortical Caudate Nucleus in Attention Deficit Hyperactivity Disorder Boys with a Comorbid Reading Disability

Dhruman Goradia1, Sherry Vogel1, Brianne Mohl1, Caroline Zajac-Benitez1, Dalal Khatib1, Rachel Dick1, Usha Rajan1, Olivia McGarragle1, David R. Rosenberg1, Jeffrey A. Stanley1

1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States

Attention deficit hyperactivity disorder (ADHD) and reading disability (RD) are frequently comorbid with RD coexisting in about 20-40% of cases with ADHD. However, the neuropathology differentiating ADHD with RD from ADHD without RD remains poorly understood. Reduction of caudate volume is a consistent observation in ADHD but not in RD. Because cortical projections to the striatum (caudate and putamen) are topographically organized, assessing morphological shape deformation of the striatum may implicate specific corticostriatal pathways. This study aims to assess alterations in surface deformation of the striatum that differentiate ADHD with RD from ADHD without RD and healthy control.