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Abstract #1192

High Resolution Mapping of Modafinil Induced Changes in Glutamate Level in Rat Brain

Mohammad Haris1, Anup Singh1, Kejia Cai1, Kavindra Nath2, Feliks Kogan1, Hari Hariharan1, John A. Detre1, C Neill Epperson3, Ravinder Reddy1

1CMROI, Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Molecular Imaging, University of Pennsylvania, Philadelphia, PA, United States; 3Psychiatry, University of Pennsylvania, Philadelphia, PA, United States


Modafinilis used for the treatment of narcolepsy and somnolence and is known to increase cerebral glutamate (Glu) levels. We used the GluCEST technique to measure modafinil induced Glu changes in rat brain and compared the results with Glu concentration by proton magnetic resonance spectroscopy (MRS). No immediate increases in either GluCEST or Glu concentration were observed after modafinil injection, but a significant increase in both GluCEST (194.4%) and MRS Glu concentration (224.9%) was observed 24 hours after modafinil administration.