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Abstract #1194

Neural Basis of the Association Between Remitted Geriatric Depression and APOE &[epsilon]4 Allele in the Nondemented Elderly

Hao Shu1, 2, Yonggui Yuan1, 3, Chunming Xie1, 3, Feng Bai1, 3, Jiayong You4, Lingjiang Li5, Shi-Jiang Li2, Zhijun Zhang1, 3

1Medical College of Southeast University, Institute of Neuropsychiatry, Nanjing, Jiangsu, China; 2Medical College of Wisconsin, Department of Biophysics, Milwaukee, WI, United States; 3Affiliated ZhongDa Hospital of Southeast University, Department of Neuropsychiatry, Nanjing, Jiangsu, China; 4Nanjing Brain Hospital Affliated to Nanjing Medical University, Department of Psychiatry, Nanjing, Jiangsu, China; 5Second Xiangya Hospital of Central South University, Mental Health Institute, Changsha, Hunan, China

In this study, we employed hippocampal seed-based network analysis approach and found distinct neural circuits were separately implicated in the effects of remitted geriatric depression (RGD) and apolipoprotein E (APOE) 4 allele, more importantly, the interactive effects of RGD and APOE4 allele were identified in prefrontal-temporal-occipital system, which are early targeted by Alzheimers disease progression. These findings indicated both previous depressive episode and APOE 4 allele as well as their combination could alter functional coupling of hippocampal network, which may play a critical role in the persistent cognitive impairment and the development of Alzheimers disease.