Hao Shu1,
2, Yonggui Yuan1, 3, Chunming Xie1,
3, Feng Bai1, 3, Jiayong You4,
Lingjiang Li5, Shi-Jiang Li2, Zhijun Zhang1,
3
1Medical
College of Southeast University, Institute of Neuropsychiatry, Nanjing,
Jiangsu, China; 2Medical College of Wisconsin, Department of Biophysics,
Milwaukee, WI, United States; 3Affiliated ZhongDa Hospital of
Southeast University, Department of
Neuropsychiatry, Nanjing, Jiangsu, China; 4Nanjing Brain
Hospital Affliated to Nanjing Medical University, Department of Psychiatry,
Nanjing, Jiangsu, China; 5Second Xiangya Hospital of Central South
University, Mental Health Institute, Changsha, Hunan, China
In this study, we employed hippocampal seed-based network analysis approach and found distinct neural circuits were separately implicated in the effects of remitted geriatric depression (RGD) and apolipoprotein E (APOE) 4 allele, more importantly, the interactive effects of RGD and APOE4 allele were identified in prefrontal-temporal-occipital system, which are early targeted by Alzheimers disease progression. These findings indicated both previous depressive episode and APOE 4 allele as well as their combination could alter functional coupling of hippocampal network, which may play a critical role in the persistent cognitive impairment and the development of Alzheimers disease.