Sean Nicholas Hatton1, Jim Lagopoulos1, Daniel F. Hermens1, Elizabeth Nicholas Scott1, Ian B. Hickie1, Maxwell R. Bennett1
1Clinical Research Unit, Brain & Mind Research Institute, Camperdown, NSW, Australia
We investigated cortical changes in young people with psychosis or bipolar disorder and the relationship between cortical thinning and neurocognitive performance. Although the groups exhibited some differences in regional cortical thinning, the shared regions of cortical thinning were correlated with neurocognitive deficits in visual sustained attention, semantic verbal fluency, and verbal learning and memory that are commonly reported in young people with either psychosis or bipolar disorder. While these disorders may have differing neuropathological origins, it is these shared regions of cortical thinning that most significantly impact the lives of young people with psychosis or bipolar disorder.