Hong Yang1, Manli Huang2, Qidong Wang1, Zhan Feng1
1Department of Radiology, First Affiliated Hospital of College of Medical Science, Zhejiang University, Hangzhou, Zhejiang, China; 2Department of Psychiatry, First Affiliated Hospital of College of Medical Science, Zhejiang University, Hangzhou, Zhejiang, China
Using ALFF approach, we are to test the hypothesis of the abnormal neural activities in the prefrontallimbic networks in drug-nave, first episode depression. Twenty-three patients and twenty controls were recruited. Twenty-two axial slices covering whole brain were acquired. Data processing was performed using DPARS software. Compared to controls, a significant increased ALFF in right frontal lobe and a significant decreased ALFF in right cerebellum, right occipital lobe as well as right parahippocampa gyrus were showed in patients. The abnormal neuronal activity in resting state support a model of dysfunction in the prefrontallimbic networks in first episode depression.