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Abstract #1204

Chronic Exposure of Neurotoxic Doses of D-Amphetamine Potentiates the Central Effect of an Acute Challenge with Methylphenidate.

A. Schrantee1, 2, J.L. Tremoleda2, M. Wylezinska-Arridge2, W. Gsell2, L. Reneman1

1Academic Medical Center, Amsterdam, Netherlands; 2MRC Clinical Sciences Centre, Biological Imaging Centre, London, United Kingdom

This study assesses whether phMRI is a valid tool to study the sensitivity to study moderate DA dysfunction. To this end we administered dAMPH chronically and assessed the BOLD response to a MPH challenge.