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Abstract #1212

New Acquisition and Analysis for Segmentation of the Intraorbital Optic Nerve in vivo at 3T

Marios C. Yiannakas1, Ahmed T. Toosy1, Rhian E. Raftopoulos1, Raj Kapoor1, David H. Miller1, Claudia Angela M. Wheeler-Kingshott1

1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom

A new image acquisition and analysis protocol is presented here for fast and reliable segmentation of the intraorbital optic nerve which employs an improved image acquisition scheme in conjunction with a robust image analysis method commonly used for the segmentation of the cervical cord, a similar model to the intraorbital optic nerve. The images obtainable with the use of the proposed acquisition protocol allow highly reproducible measurements of the mean cross-sectional area of the intraorbital optic nerve.