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Abstract #1231

Pretreatment Dynamic Contrast-Enhanced and Diffusion MRI in Predicting Locoregional Control in Oropharyngeal or Hypopharyngeal Cancer Treated with Chemoradiation

Yu-Chun Lin1, Jiun-jie Wang2, Shu-Hang Ng1

1Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, Linkou, 333, Taiwan; 2Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, 333, Taiwan

Fifty-four patients with hypopharyngeal squamous cell carcinoma underwent dynamic contrast enhanced MRI and diffusion weighted imaging in a 3T MRI scanner. The Ktrans(tumor) of locoregional control (LRC) group was significantly higher than that of the locoregional failure (LRF) group. The Ktrans(node) of the LRC group was also higher than that of the LRF group with borderline significance. No significant difference was found in ADC(tumor) or ADC(node) between the two groups. Ktrans(tumor) of 0.45,determined by the receiver operating characteristic curve as a cutoff value for predicting local failure, attained 78.6% sensitivity of and 77.8% specificity