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Abstract #1240

Automatic Nonlinear Transformation to Talairach Stereotaxic Space with Quality Assurance

Mingyi Li1, Blessy Mathew1, Katherine Koenig1, Jian Lin1, Michael Phillips1, Mark J. Lowe1

1Cleveland Clinic, Cleveland, OH, United States

Transforming MRI brain images into Talairach space will greatly facilitate the comparison of neuroimaging research results across subjects and applications of atlas to research subjects and clinical patients. We developed an automatic processing pipeline based on nonlinear registration to transform brain images to Talairach space. The pipeline depended on matching scores derived from brain parcellation for quality assurance. The pipeline was tested on subjects including five controls and eleven patients with high EDSS score. The results showed the new method had significant improvement on the matching accuracy for both control and patients over two widely used methods.