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Abstract #1254

Physiology-Based MRI Assessment of CSF Flow at the Foramen Magnum with a Valsalva Maneuver

Samuel Patz1, 2, Yansong Zhao3, Neel Madan4, Mark E. Wagshul5, James P. Butler, 26, Rafeeque A. Bhadelia, 27

1Radiology, Brigham & Women's Hospital, Boston, MA, United States; 2Harvard Medical School, Boston, MA, United States; 3Philips Healthcare, Columbus, OH, United States; 4Radiology, Tufts Medical Center, Boston, MA, United States; 5Gruss Magnetic Resonance Research Center, Albert Einstein College of Medicine, Bronx, NY, United States; 6Sleep Medicine, Brigham & Womens Hospital, Boston, MA, United States; 7Radiology, Beth Isarael Deaconess Medical Center, Boston, MA, United States

Two MRI methods, 2D cine-PC and 1D Pencil Bean Imaging (PBI), were evaluated in healthy subjects for their ability to dynamically measure CSF flow during the physiological challenge of a Valsalva maneuver. Both fast cine-PC and PBI demonstrated expected changes in CSF flow with Valsalva maneuver in normal subjects. The real-time capability of PBI has the potential to detect Valsalva-related transient CSF flow obstruction in patients with Chiari I malformation.