Abstract #1257

Aging Deficits in Axonal Transport Are Exacerbated by Abeta Plaques: An MEMRI Study

Elaine L. Bearer¹,², Joseph J. Gallagher², Aaron Gonzales³, XiaoWei Zhang², Russell E. Jacobs⁴

¹Pathology, University of New Mexico, Health Sciences Center, Albuquerque, NM, United States; ²Biology, California Institute of Technology, Pasadena, CA, United States; ³Pathology, University of New Mexico, Health Sciences Center, Abuquerque, NM, United States; ⁴Beckman Institute, California Institute of Technology, Pasadena, CA, United States

Transport defects impact neuronal survival. We are developing and applying high-field MEMRI to detect and measure transport dynamics in living mouse models of neurodegenerative diseases. Here we present results from the aged double transgenic mice expressing human mutant amyoid precursor protein under control of the Tet-off promotor. Statistical parametric mapping and ROI analyses demonstrate decreased Mn2+ accumulation in the contralateral hippocampus and the medial septal nuclei in the forebrain after injection in the right hippocampus in aged versus young mice which is exacerbated with in the APP over-expressors who also display numerous Abeta plaques.