Pan-ki Kim1,
Bong-sik Jeon2, Eun-Ah Park3, Eung-Gyu Kim2,
Wan-Jae Myeong2, Whal Lee3
1Seoul
National University, Seoul, Korea; 2Hanwha Chemical, Daejeon,
Korea; 3Seoul National University Hospital, Seoul, Korea
Recently developed extremely small-sized iron oxide nanoparticles (ESION) contrast agent was made of 3 nm-sized nanoparticles. So that can be utilized as T1 contrast agent like a gadolinium based contrast material due to have a character of high r1, low r2/r1 ratio and long blood half-life, as previous study. This study was carried out to evaluate whether ESION is clinically useful through the rabbit thigh vessels MR angiography that acquired first-pass and equilibrium 3D MR angiography with high spatial resolution to compare with conventional Gd-CE MR angiography and a reference standard digital subtraction angiography (DSA).