A Realistic 4D Numerical Phantom for Quantitative First-Pass Myocardial Perfusion MRI

Lukas Wissmann¹, Johannes F.M. Schmidt¹, Sebastian Kozerke¹

The development of novel cardiac MRI methodology requThe development of novel cardiac MRI methodology requires simulation of both anatomical and functional information. To date, most numerical and physical phantoms tend to oversimplify anatomy and/or physiology. This study proposes a realistic 4D numerical phantom for quantitative myocardial perfusion MRI based on the XCAT model. It incorporates information about anatomy as well as dynamic contrast enhancement and, optionally, cardiac and respiratory motion. As an example application, the impact of dose and T1 uncertainty on myocardial blood flow quantification are studied.