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Abstract #1330

Evaluating the Reproducibility and Regional Variation of Wall Shear Stress in Rat Model with the Use of Flow-Sensitive MRI

Shin-Lei Peng1, Hsu-Hsia Peng1, Tao-Chieh Yang2, Jee-Ching Hsu3, Yi-Chun Wu4, Fu-Nien Wang1

1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 2Department of Neurosurgy, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 3Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 4Animal Molecular Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

This study concentrated on the wall shear stress (WSS) of common carotid arteries (CCA) in the spontaneously hypertensive rat (SHR) via phase-contrast MRI. The reproducibility of measured WSS and regional variations of WSS at vascular segment were also computed. The WSS in the bifurcation of CCA (CCAbifur ) of SHR was significantly lower than that in the normotensive Wistar Kyoto (WKY) rats. Reproducibility measurements of intra-observer and intra-scan exhibited good agreements. Furthermore, relative lower WSS at the posterior of CCAbifur was observed in SHR. The feasibility and reproducibility of WSS measurements could benefit longitudinal studies on SHR.