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Abstract #1351

High Temporal Resolution, Simultaneous Quantification of Intravascular Blood Flow and Oxygen Saturation with BRISK K-Space Sampling

Zachary Rodgers1, Lohith Kini1, Varsha Jain1, Michael C. Langham1, Jeremy F. Magland1, Felix W. Wehrli1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

A dual-echo phase contrast pulse sequence with BRISK k-space sampling was used to quantify intravascular blood flow and oxygen saturation (%HbO2) simultaneously at 2 s temporal resolution. BRISK sampling was shown to have improved motion sensitivity compared to keyhole as well as improved ability to resolve changes in blood flow and %HbO2 during dynamic physiologic paradigms in both the cerebral and peripheral veins. Applications of this pulse sequence include high temporal resolution quantification of cerebral metabolism and evaluation of peripheral artery disease in response to post-occlusion reactive hyperemia in the leg.