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Abstract #1364

An Efficient Protocol for Infarct Quantification in Mice

Guido Buonincontri1, Carmen Methner2, Thomas Krieg2, T. Adrian Carpenter1, Stephen J. Sawiak1, 3

1Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom; 2Department of Medicine, University of Cambridge, Cambridge, United Kingdom; 3Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom

Late gadolinium enhancement is a remarkably accurate way of assessing tissue viability after myocardial infarction. Performing this technique in mice is useful for translational drug studies carried out longitudinally in order to monitor adverse remodeling. In mice, high cardiac rate and small size mean that standard TI-optimised inversion recovery is not as efficient as in humans. To achieve LGE imaging efficiently we propose and validate a multi-slice method with an optimised acquisition scheme. Our method achieves excellent hyperenhancement and CNR and does not require TI optimization.